Neurotrope To Present Bryostatin Phase 2 Data In An Oral Presentation At AAIC 2017 Meeting

NEW YORK - June 29, 2017- Neurotrope Inc. (NASDAQ: NTRP) today announced the acceptance of a late breaking oral presentation at the Alzheimer's Association International Conference 2017 (AAIC) being held in London from July 16 - 20, 2017.

The presentation will be given by Dr. Martin R. Farlow, MD, Vice-Chairman for Research in the Department of Neurology, Indiana University School of Medicine, Indiana Alzheimer Disease Center. It will feature results from Neurotrope’s recently completed Phase 2 study of bryostatin - a protein kinase C epsilon (PKCe) modulator - in the treatment of patients with moderate-severe to severe AD. The study was designed to assess the dosing, safety, and preliminary efficacy for 2 different doses of bryostatin versus placebo.

Details of the presentation are as follows:
Date: Wednesday, 19 July, 2017
Presentation Time: 4:15 PM to 4:30PM
Location: Excel London Auditorium
Session Name: DT-02 Developing Topics: Clinical Trials
Presentation Title: DT-02-01: Effect of Bryostatin-1 on Cognition and Daily Living Tasks in Moderate to Severe
Alzheimer's disease Preliminary Report of a Phase 2 Study.

“Our understanding of bryostatin, its target PKCe, and the roles that PKCe plays in synaptogenesis, prevention of neuronal death, and anti-amyloid, anti-tau activity has emerged from discoveries that have been made over nearly three decades of research and development at the National Institutes of Health, Blanchette Rockefeller Neurosciences Institute at WVU, and at Neurotrope," said Dr. Daniel Alkon, MD, President and Chief Scientific Officer of Neurotrope. "We, at Neurotrope, are delighted to have this opportunity to share the molecular basis of our research, along with the results of our Phase 2 study, with the world leaders in AD who will be attending the AAIC meeting in London.”

About Bryostatin

Bryostatin-1 is the first PKCe modulator to be tested in a phase 2 clinical study for patients suffering from moderate to severe AD — a difficult to treat population.

The rationale for researching this novel mechanism in AD results from in vitro and in vivo models of AD demonstrating that modulation of PKCe by Bryostatin-1 enhances synaptogenesis and prevents neuronal death. As synaptic loss is tightly correlated with cognitive impairment in AD, this attribute of the molecule made bryostatin an intriguing candidate for additional investigation in dementia. Furthermore, preclinical studies also demonstrated bryostatin reduces toxic Aß levels, prevents plaque formation, inhibits tau phosphorylation, and enhances cognition. Thus the multimodal effects of this first PKCe modulator offer an attractive new mechanism to study in AD with the ultimate goal to slow or prevent the progression of disease.

About Neurotrope

Neurotrope is at the forefront of developing a new approach to combatting AD and other neurodegenerative diseases. The Company's world-class science offers the potential to realize a paradigm shift to overcome one of today’s most challenging clinical problems — finding a way to slow or even prevent the progression of AD.

In addition to the Company’s Phase 2 trial of bryostatin-1 in moderate to severe AD, Neurotrope has also conducted preclinical studies of bryostatin as a potential treatment for Fragile X Syndrome, Niemann-Pick Type C disease and Rett Syndrome—three rare genetic diseases for which only symptomatic treatments are currently available. The FDA has granted Orphan Drug Designation to Neurotrope for Bryostatin-1 as a treatment for Fragile X Syndrome. Bryostatin-1 has already undergone testing in more than 1,500 people in cancer studies, thus creating a large safety data base that will further inform clinical trial designs in AD.

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