Bristol-Myers Squibb To Present New Research Related To The Treatment Of Rheumatoid Arthritis Patients With Highly Active, Progressive Disease At The Annual European Congress Of Rheumatology (EULAR 2017)
Key analyses focus on treatment outcomes among RA patients with a traditionally poor prognosis
ORENCIA® (abatacept) continuing research underscores Bristol-Myers Squibb’s commitment to advancing the science of modulating the body’s immune response to treat disease
PRINCETON, N.J.--(BUSINESS WIRE)--Bristol-Myers Squibb Company (NYSE:BMY) today confirmed that 23 abstracts related to ORENCIA® (abatacept), including new data on the role of biomarkers and MRI in RA patient identification and treatment, will be presented at the Annual European Congress of Rheumatology (EULAR 2017), June 14-17 in Madrid, Spain. The Company also will share first-in-human data from BMS-986165, an investigational TYK2 inhibitor.
Bristol-Myers Squibb has played a leading role for more than two decades in discovering and developing medicines designed to help modulate the body’s immune response to treat disease. The abstracts from Bristol-Myers Squibb accepted for EULAR 2017 include three practice-informing analyses pertaining to ORENCIA treatment responses in patients with highly active, progressive rheumatoid arthritis (RA), who traditionally have a poor prognosis. 1-3
- A post hoc analysis of the phase 3 AGREE* clinical trial showing that among patients with early, erosive RA, treatment with ORENCIA + MTX (vs. MTX alone) resulted in higher seroconversion rates.2 Seroconversion refers to the RA autoantibodies ACPA and RF – anti-citrullinated protein antibodies and rheumatoid factor – falling to undetectable levels among patients who entered the trial with measurable (seropositive) levels.2 ACPA and RF are biomarkers associated with poor prognosis in RA.2 The full data analysis will be featured in a poster tour on Friday, June 16, from 11:45 – 13:30 CET.
- A post hoc analysis of the phase 3b AVERT** study (MTX versus Orencia+MTX) evaluating the proportion of patients achieving remission at 12 months as measured by baseline MRI-detected inflammation status.3 The analysis explored the response of patients with higher inflammation levels at baseline – as measured by MRI – versus patients with lower baseline levels.3 The full data analysis will be featured in an oral presentation on Friday, June 16, at 10:30 CET.
- A post hoc analysis of the phase 3b AMPLE*** study that investigated the efficacy of ORENCIA+MTX versus the TNF inhibitor adalimumab+MTX in patients with seropositive, erosive early RA.1 The analysis looked at differences in treatment effect between the two regimens among patients with seropositive, erosive early RA. The full data analysis will be featured in a poster tour on Saturday, June 17, from 10:15 – 12:00 CET.
“The research Bristol-Myers Squibb is presenting at EULAR 2017 shows our commitment to advancing scientific understanding of how biomarkers and tools, such as MRI, can be used to guide patient selection and treatment in highly active, progressive rheumatoid arthritis,” said Brian J. Gavin, Vice President, ORENCIA Development Lead at Bristol-Myers Squibb. “Importantly, the research also yields critical insights into the role of modulating the body’s immune system in rheumatoid arthritis and potentially other autoimmune conditions where we are committed to making a meaningful, positive impact on patients’ lives.”
In RA, the body’s immune system mistakenly attacks the joints.4 The costimulation blockade of ORENCIA prevents T-cell activation and the resulting cascade of events that contribute to joint destruction.
The full listing of abstracts Bristol-Myers Squibb will present at EULAR 2017, including data and analyses in rheumatoid arthritis, polyarticular juvenile idiopathic arthritis and psoriatic arthritis, follows. Complete abstracts can be accessed online here.